(6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane

Base Information

Chemical Name:(6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane
CAS No.:1161000-19-6
Molecular Formula:C₇H₁₄N₂O
Molecular Weight:142.201
Hs Code.:
Mol file:1161000-19-6.mol

Synonyms:(6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane;(7R,8aS)-rel-Octahydropyrrolo[1,2-a]pyrazin-7-ol

Suppliers and Price of (6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(7R,8aS)-Octahydropyrrolo[1,2-a]pyrazin-7-ol
2.5mg
$ 45.00

Chemenu
cis-Octahydropyrrolo[1,2-a]piperazin-7-ol 95%+
250mg
$ 1509.00

Chemenu
cis-Octahydropyrrolo[1,2-a]piperazin-7-ol 95%+
100mg
$ 939.00

Chemenu
cis-Octahydropyrrolo[1,2-a]piperazin-7-ol 95%+
1g
$ 2180.00

American Custom Chemicals Corporation
OCTAHYDRO-PYRROLO[1,2-A]PYRAZIN-7-OL 97.00%
5G
$ 3054.98

American Custom Chemicals Corporation
OCTAHYDRO-PYRROLO[1,2-A]PYRAZIN-7-OL 97.00%
1G
$ 1691.79

Alichem
(7R,8aS)-rel-Octahydropyrrolo[1,2-a]pyrazin-7-ol
250mg
$ 873.57

Total 8 raw suppliers

Chemical Property of (6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane

Chemical Property:

PSA：35.50000
LogP:-0.70850

Purity/Quality:

97% ^*data from raw suppliers

(7R,8aS)-Octahydropyrrolo[1,2-a]pyrazin-7-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane

There total 17 articles about (6S,8R)-8-Hydroxy-1,4-diazabicyclo-[4.3.0]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.1%

: 879399-06-1
(7R,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-7-yl benzoate

: 1161000-19-6
(7R,8AS)-7-hydroxy-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]-pyrazine

Guidance literature:: (7R,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-7-yl benzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1161000-19-6
(7R,8AS)-7-hydroxy-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]-pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 5 h / Reflux

2: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 16 h / 50 °C / 1551.49 Torr

With lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; ethanol; benzene;