(4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Base Information

Chemical Name:(4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester
CAS No.:125982-19-6
Molecular Formula:C12H23NO5
Molecular Weight:261.318
Hs Code.:
Mol file:125982-19-6.mol

Synonyms:(4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Suppliers and Price of (4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

Chemical Property:

Boiling Point:388.3±37.0 °C(Predicted)
PKA:11.88±0.46(Predicted)
PSA：84.86000
Density:1.087±0.06 g/cm3(Predicted)
LogP:1.60620

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester

There total 6 articles about (4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-hydroxypentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 65487-73-2
(S)-2-((tert-butoxycarbonyl)amino)-5-ethoxy-5-oxopentanoic acid

: 125982-19-6
ethyl (4S)-N-(t-butyloxycarbonyl)amino-5-hydroxypentanoate

Guidance literature:: With borane; In tetrahydrofuran; at -15 ℃; for 13h;
DOI:10.1021/ja00382a054

Reference yield:

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

: 125982-19-6
ethyl (4S)-N-(t-butyloxycarbonyl)amino-5-hydroxypentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaHCO₃ / dioxane / Ambient temperature

2: DCC / ethyl acetate / 0 - 20 °C

3: NaBH₄ / tetrahydrofuran; ethanol / 0.25 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate;
DOI:10.1016/S0957-4166(98)00466-2

Reference yield:

: 691-64-5
di-tert-butyl oxalate

: 125982-19-6
ethyl (4S)-N-(t-butyloxycarbonyl)amino-5-hydroxypentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: NEt₃ / dimethylformamide; H₂O / 4 h / Ambient temperature

2: 57 percent / BH₃ / tetrahydrofuran / 13 h / -15 °C

With borane; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00382a054