(3β,22S)-Dihydroxy Cholesterol

Base Information

Chemical Name:(3β,22S)-Dihydroxy Cholesterol
CAS No.:26649-05-8
Molecular Formula:C₂₇H₄₆O₃
Molecular Weight:418.66
Hs Code.:
Mol file:26649-05-8.mol

Synonyms:(3β,22S)-Dihydroxy Cholesterol;(20R,22S)-20,22-Dihydroxycholesterol;(22S)-Cholest-5-ene-3β,20,22-triol;(3β,22S)-Cholest-5-ene-3,20,22-triol;20α,22S-Dihydroxycholesterol

Suppliers and Price of (3β,22S)-Dihydroxy Cholesterol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3β,22S)-DihydroxyCholesterol
2.5mg
$ 165.00

American Custom Chemicals Corporation
(3-BETA,22-S)-DIHYDROXY CHOLESTEROL 95.00%
5MG
$ 501.69

Total 4 raw suppliers

Chemical Property of (3β,22S)-Dihydroxy Cholesterol

Chemical Property:

Melting Point:181-190 °C(Solv: acetone (67-64-1); chloroform (67-66-3))
Boiling Point:553.5±25.0 °C(Predicted)
PKA:14.42±0.29(Predicted)
PSA：60.69000
Density:1.08±0.1 g/cm3(Predicted)
LogP:5.47440

Purity/Quality:

99% ^*data from raw suppliers

(3β,22S)-DihydroxyCholesterol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Cholesterol (C432501). Cholesterol is metabolized to Pregnenolone by way of 22R-hydroxycholesterol and 20R,22R-dihydroxycholesterol by P 450scc.

Technology Process of (3β,22S)-Dihydroxy Cholesterol

There total 13 articles about (3β,22S)-Dihydroxy Cholesterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036954-89-8
(20R,22S)-3β-(tert-butyldimethylsilyl)oxycholest-5-ene-20,22-diol

: 26649-05-8,15234-55-6
(20R,22S)-cholest-5-ene-3β,20,22-triol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 96h;
DOI:10.1016/j.steroids.2004.04.005

Reference yield:

: 145-13-1
Pregnenolone

: 26649-05-8,15234-55-6
(20R,22S)-cholest-5-ene-3β,20,22-triol

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole / dimethylformamide / 120 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

2.2: hexane; tetrahydrofuran / 0.17 h

3.1: H₂ / Lindlar catalyst / ethyl acetate; quinoline / 1.5 h / 20 °C

3.2: H₂ / Lindlar catalyst / ethyl acetate / 0.33 h / 20 °C

4.1: 7.18 g / VO(acac)2; TBHP / CH₂Cl₂ / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 0 - 20 °C

6.1: 3.43 g / TBAF / tetrahydrofuran / 96 h / 20 °C

With 1H-imidazole; tert.-butylhydroperoxide; lithium aluminium tetrahydride; n-butyllithium; bis(acetylacetonate)oxovanadium; tetrabutyl ammonium fluoride; hydrogen; Lindlar's catalyst; In tetrahydrofuran; quinoline; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.steroids.2004.04.005

Reference yield:

: 58701-45-4
3β-t-butyldimethylsilyloxy-pregn-5-en-20-one

: 26649-05-8,15234-55-6
(20R,22S)-cholest-5-ene-3β,20,22-triol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: hexane; tetrahydrofuran / 0.17 h

2.1: H₂ / Lindlar catalyst / ethyl acetate; quinoline / 1.5 h / 20 °C

2.2: H₂ / Lindlar catalyst / ethyl acetate / 0.33 h / 20 °C

3.1: 7.18 g / VO(acac)2; TBHP / CH₂Cl₂ / 20 °C

4.1: LiAlH₄ / tetrahydrofuran / 0 - 20 °C

5.1: 3.43 g / TBAF / tetrahydrofuran / 96 h / 20 °C

With tert.-butylhydroperoxide; lithium aluminium tetrahydride; n-butyllithium; bis(acetylacetonate)oxovanadium; tetrabutyl ammonium fluoride; hydrogen; Lindlar's catalyst; In tetrahydrofuran; quinoline; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/j.steroids.2004.04.005