Methyl 2-chloro-6-morpholin-4-ylisonicotinate

Base Information

• Chemical Name: Methyl 2-chloro-6-morpholin-4-ylisonicotinate
• CAS No.: 1201675-09-3
• Molecular Formula: C₁₁H₁₃ClN₂O₃
• Molecular Weight: 256.689
• Hs Code.: 2933399990
• Mol file: 1201675-09-3.mol

Synonyms:Methyl 2-chloro-6-morpholin-4-ylisonicotinate

Chemical Property of Methyl 2-chloro-6-morpholin-4-ylisonicotinate

Chemical Property:

• PSA: 51.66000
• LogP: 1.42320

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-chloro-6-morpholin-4-ylisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-chloro-6-morpholin-4-ylisonicotinate

There total 2 articles about Methyl 2-chloro-6-morpholin-4-ylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

morpholine (110-91-8,99108-56-2) + methyl 2,6-dichloroisonicotinate (42521-09-5) → methyl 2-chloro-6-morpholinoisonicotinate (1201675-09-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 45h; Reflux;

DOI:10.1021/acs.jmedchem.0c01441

Reference yield:

→ methyl 2-chloro-6-morpholinoisonicotinate (1201675-09-3)

Guidance literature:

Reference yield: 99.0%

methyl 2-chloro-6-morpholinoisonicotinate (1201675-09-3) → 2-Chloro-6-morpholinoisonicotinic acid (56835-97-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

DOI:10.1021/acs.jmedchem.0c01441

upstream raw materials:

morpholine

methyl 2,6-dichloroisonicotinate

Downstream raw materials:

2-Chloro-6-morpholinoisonicotinic acid