N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide

Base Information

Chemical Name:N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
CAS No.:1105698-15-4
Molecular Formula:C26H22N2O2
Molecular Weight:394.473
Hs Code.:
Mol file:1105698-15-4.mol

Synonyms:N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide;Salermide;N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

Suppliers and Price of N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Salermide
10mg
$ 366.00

Usbiological
Salermide
5mg
$ 319.00

TRC
Salermide
10mg
$ 100.00

Tocris
Salermide ≥98%(HPLC)
50
$ 378.00

Tocris
Salermide ≥98%(HPLC)
10
$ 90.00

Sigma-Aldrich
SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem
10 mg
$ 146.15

Sigma-Aldrich
Salermide ≥98% (HPLC)
5mg
$ 146.00

Sigma-Aldrich
SIRT1/2 Inhibitor VIII, Salermide
10mg-m
$ 158.00

Sigma-Aldrich
Salermide ≥98% (HPLC)
25mg
$ 590.00

DC Chemicals
Salermide >98%
1 g
$ 1600.00

Total 16 raw suppliers

Chemical Property of N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide

Chemical Property:

Boiling Point:666.7±50.0 °C(Predicted)
PKA:7.90±0.50(Predicted)
PSA：61.69000
Density:1.16±0.1 g/cm3(Predicted)
LogP:6.11120
Storage Temp.:Store at +4°C
Solubility.:DMSO: >10mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

Salermide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 43-52/53
Safety Statements: 36/37-61

MSDS Files:: SDS file from LookChem

Useful:

Description The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1.
Uses Salermide is an inhibitor of SIRT1, SIRT2, and HDAC.

Technology Process of N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide

There total 2 articles about N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1105698-16-5
(R/S)-N-(3-aminophenyl)-2-phenylpropanamide

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 1105698-15-4
salermide

Guidance literature:: With acetic acid; In ethanol; benzene; Reflux;
DOI:10.1021/jm3011614

Reference yield:

: 492-37-5,2328-24-7
hydratropic acid

: 108-45-2,64554-26-3,76583-20-5
m-phenylenediamine

: 1105698-15-4
salermide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

2: acetic acid / ethanol; benzene / Reflux

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; In ethanol; benzene;
DOI:10.1021/jm3011614