7-(benzoylamino)heptanoic acid

Base Information

Chemical Name:7-(benzoylamino)heptanoic acid
CAS No.:1149-15-1
Molecular Formula:C43H48Cl3NO15
Molecular Weight:249.31
Hs Code.:
Mol file:1149-15-1.mol

Synonyms:N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel;N-Debenzoyl-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]taxol

Suppliers and Price of 7-(benzoylamino)heptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 7-(benzoylamino)heptanoic acid

Chemical Property:

PSA：66.40000
LogP:2.84240

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-(benzoylamino)heptanoic acid

There total 11 articles about 7-(benzoylamino)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 65-85-0,8013-63-6
benzoic acid

: 929-17-9
7-aminoheptanoic acid

: 1149-15-1
7-(benzoylamino)heptanoic acid

Guidance literature:: benzoic acid; With pyridine; pentafluorophenyl trifloroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

7-aminoheptanoic acid; With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/cbdv.201200076

Reference yield:

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 1149-15-1
7-(benzoylamino)heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / EDCI; HOBT; N-methylmorpholine / dimethylformamide / 18 h

2: LiOH*H₂O / tetrahydrofuran; H₂O

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm015568c