Faldaprevir

Base Information

• Chemical Name: Faldaprevir
• CAS No.: 801283-95-4
• Molecular Formula: C₄₀H₄₉BrN₆O₉S
• Molecular Weight: 869.834
• Mol file: 801283-95-4.mol

Synonyms:BI 201335;Faldaprevir;Faldaprevir(BI 201335);(1R,2S)-N-[(Cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-bromo-7-methoxy-2-[2-[(2-methyl-1-oxopropyl)amino]-4-thiazolyl]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethenyl-cyclopropanecarboxylic acid

Chemical Property of Faldaprevir

Chemical Property:

• PSA: 226.62000
• LogP: 7.09390

Purity/Quality:

98% min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Faldaprevir

There total 2 articles about Faldaprevir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C41H51BrN6O9S (1219105-49-3) → faldaprevir (801283-95-4)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm100690x

Reference yield: 52.0%

C17H15BrClN3O2S (1219105-47-1) + C23H35N3O7 (1098182-10-5) → faldaprevir (801283-95-4)

Guidance literature:

C₂₃H₃₅N₃O₇; With potassium tert-butylate; In dimethyl sulfoxide; for 1h; Inert atmosphere; Cooling;

C₁₇H₁₅BrClN₃O₂S; In dimethyl sulfoxide; at 20 ℃; for 3h; Inert atmosphere; Darkness;

With hydrogenchloride; In water;

upstream raw materials:

C₁₇H₁₅BrClN₃O₂S

C₂₃H₃₅N₃O₇

C₄₁H₅₁BrN₆O₉S

Refernces

• 1、 Llinàs-Brunet, Montse,Bailey, Murray D.,Goudreau, Nathalie,Bhardwaj, Punit K.,Bordeleau, Josée,B?s, Michael,Bousquet, Yves,Cordingley, Michael G.,Duan, Jiamin,Forgione, Pat,Garneau, Michel,Ghiro, Elise,Gorys, Vida,Goulet, Sylvie,Halmos, Ted,Kawai, Stephen H.,Naud, Julie,Poupart, Marc-André,White, Peter W.. "Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335)". experimental part. p. 6466 - 6476. Retrieved 2010/11/04.