R-(-)-2,5-Dimethoxy-4-bromoamphetamine

Base Information

• Chemical Name: R-(-)-2,5-Dimethoxy-4-bromoamphetamine
• CAS No.: 43061-15-0
• Molecular Formula: C11H16BrNO2
• Molecular Weight: 274.158
• UNII: C918IS60W6
• ChEMBL ID: CHEMBL69700
• DSSTox Substance ID: DTXSID70109993
• Nikkaji Number: J259.909K
• Pharos Ligand ID: C9G1P1BUVXT9
• Wikidata: Q27275334
• Mol file: 43061-15-0.mol

Synonyms:Brolamfetamine, (R)-;R-(-)-2,5-Dimethoxy-4-bromoamphetamine;(-)-Dob;43061-15-0;UNII-C918IS60W6;(-)-2,5-Dimethoxy-4-bromoamphetamine;C918IS60W6;CHEMBL69700;Benzeneethanamine, 4-bromo-2,5-dimethoxy-alpha-methyl-, (alphaR)-;Benzeneethanamine, 4-bromo-2,5-dimethoxy-alpha-methyl-, (R)-;(R)-brolamfetamine;SCHEMBL1048339;DOB, (R)-;DTXSID70109993;BDBM50064708;PDSP2_001350;(R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine;Q27275334;(R)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine;BENZENEETHANAMINE, 4-BROMO-2,5-DIMETHOXY-.ALPHA.-METHYL-, (R)-;BENZENEETHANAMINE, 4-BROMO-2,5-DIMETHOXY-.ALPHA.-METHYL-, (.ALPHA.R)-

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Chemical Property of R-(-)-2,5-Dimethoxy-4-bromoamphetamine

Chemical Property:

• Boiling Point: 340.8±37.0 °C(Predicted)
• PKA: 9.41±0.10(Predicted)
• PSA: 44.48000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 3.05630
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 273.03644
• Heavy Atom Count: 15
• Complexity: 191

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1OC)Br)OC)N
• Isomeric SMILES: C[C@H](CC1=CC(=C(C=C1OC)Br)OC)N

Technology Process of R-(-)-2,5-Dimethoxy-4-bromoamphetamine

There total 4 articles about R-(-)-2,5-Dimethoxy-4-bromoamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethyl]-((R)-1-phenyl-ethyl)-amine; hydrochloride → (-)-Brolamfetamine (43061-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / methanol; H₂O

2: Br₂ / acetic acid

With hydrogen; bromine; palladium on activated charcoal; In methanol; water; acetic acid;

DOI:10.1021/jm00263a013

Reference yield:

(-)-DMA (58993-81-0) → (-)-Brolamfetamine (43061-15-0)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid;

DOI:10.1021/jm00256a016

Reference yield:

{(S)-1-[(R)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester → (-)-Brolamfetamine (43061-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂, Pd-C, (ii) PhNCS, (iii) CF₃CO₂H

2: Br₂, HBr / acetic acid

With hydrogen bromide; bromine; In acetic acid;

DOI:10.1021/jm00256a016

upstream raw materials:

(-)-DMA