Etelcalcetide

Base Information

• Chemical Name: Etelcalcetide
• CAS No.: 1262780-97-1
• Molecular Formula: C38H73N21O10S2
• Molecular Weight: 1048.25
• Mol file: 1262780-97-1.mol

Synonyms:Etelcalcetide

Chemical Property of Etelcalcetide

Chemical Property:

• PKA: 2.01±0.10(Predicted)
• PSA: 608.31000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: 1.67200

Purity/Quality:

99% ^*data from raw suppliers

Etelcalcetide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Clinical Use: Synthetic peptide calcimimetic agent:Treatment of secondary hyperparathyroidism in patients on haemodialysis
• Drug interactions: Potentially hazardous interactions with other drugs Avoid with cinacalcet.

Technology Process of Etelcalcetide

There total 14 articles about Etelcalcetide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

S-trityl-L-cysteine (2799-07-7) + Ac-D-Cys(Trt)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 tetrahydrochloride → etelcalcetide (1262780-97-1)

Guidance literature:

With hydrogenchloride; iodine; In methanol; water; pH=1.85;

Reference yield: 60.0%

Fmoc-D-Cys (Mtt)-OH (1198791-73-9,177582-21-7) + N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine (76880-29-0) + acetic anhydride (108-24-7) + N-(9-fluorenylmethoxycarbonyl)-D-alanine (35661-38-2,35661-39-3,79990-15-1,136132-75-7) + N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine (187618-60-6) → etelcalcetide (1262780-97-1)

Guidance literature:

N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; With 4-(2,4-dimethoxyphenyl-Fmoc-aminomethyl)phenoxy resin; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 5h; rink amide resin

With piperidine; In 1-methyl-pyrrolidin-2-one; rink amide resin

Fmoc-D-Cys (Mtt)-OH; N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine; acetic anhydride; N-(9-fluorenylmethoxycarbonyl)-D-alanine; N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine; Further stages;

Reference yield:

C38H73N21O9S*C2HF3O2 + l-cysteine hydrochloride (52-89-1) → etelcalcetide (1262780-97-1)

Guidance literature:

With iodine; In methanol; water; at 20 ℃; for 8h; Sonication;

upstream raw materials:

l-cysteine hydrochloride

S-trityl-L-cysteine