Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate
• CAS No.: 132272-55-0
• Molecular Formula: C₁₁H₁₃N₃O₂
• Molecular Weight: 219.243
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80563688
• Nikkaji Number: J343.868F
• Wikidata: Q82448168

Synonyms:132272-55-0;Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate;Ethyl 8-amino-7-methylimidazo-[1,2-a]pyridine-2-carboxylate;DTXSID80563688;AKOS025393661;TS-00487;CS-0337855;Ethyl8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate;8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Chemical Property of Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate

Chemical Property:

• PSA: 69.62000
• LogP: 1.98280
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 219.100776666
• Heavy Atom Count: 16
• Complexity: 272

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 8-amino-7-methylimidazo-[1,2-a]pyridine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2C=CC(=C(C2=N1)N)C

Technology Process of Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate

There total 3 articles about Ethyl 8-Amino-7-methylimidazo[1,2-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 7-methyl-8-nitroimidazo<1,2-a>pyridine-2-carboxylate (132272-52-7) → ethyl 8-amino-7-methylimidazo<1,2-a>pyridine-2-carboxylate (132272-55-0)

Guidance literature:

With hydrogen bromide; zinc; for 3h; Ambient temperature;

DOI:10.1248/cpb.38.2352

Reference yield:

2-amino-4-methyl-3-nitropyridine (6635-86-5,67476-70-4) → ethyl 8-amino-7-methylimidazo<1,2-a>pyridine-2-carboxylate (132272-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / ethanol / 4 h / Heating

2: 70 percent / Zn/ conc.HBr / 3 h / Ambient temperature

With hydrogen bromide; zinc; In ethanol;

DOI:10.1248/cpb.38.2352

Reference yield:

ethyl Bromopyruvate (70-23-5) → ethyl 8-amino-7-methylimidazo<1,2-a>pyridine-2-carboxylate (132272-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / ethanol / 4 h / Heating

2: 70 percent / Zn/ conc.HBr / 3 h / Ambient temperature

With hydrogen bromide; zinc; In ethanol;

DOI:10.1248/cpb.38.2352

upstream raw materials:

ethyl 7-methyl-8-nitroimidazo<1,2-a>pyridine-2-carboxylate

2-amino-4-methyl-3-nitropyridine

ethyl Bromopyruvate

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