9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine

Base Information

• Chemical Name: 9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine
• CAS No.: 18551-03-6
• Molecular Formula: C₁₄H₂₈N₄O₂Si₃
• Molecular Weight: 368.658
• Mol file: 18551-03-6.mol

Synonyms:9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine

Chemical Property of 9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine

Chemical Property:

Purity/Quality:

9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.

Technology Process of 9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine

There total 1 articles about 9-(Trimethylsilyl)-2,6-bis(trimethylsiloxy)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 9-trimethylsilanyl-2,6-bis-trimethylsilanyloxy-9H-purine (18551-03-6)

Guidance literature:

DOI:10.1248/cpb.11.1470

Reference yield:

9-trimethylsilanyl-2,6-bis-trimethylsilanyloxy-9H-purine (18551-03-6) → xanthosine (146-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane / 1 h / Heating

2: NH₃ / methanol / 72 h / 24 °C

With ammonia; trimethylsilyl trifluoromethanesulfonate; In methanol; 1,2-dichloro-ethane;

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 9-trimethylsilanyl-2,6-bis-trimethylsilanyloxy-9H-purine (18551-03-6) → C31H24N4O9 (73024-64-3)

Guidance literature:

trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 1h; Yield given; Heating;

Downstream raw materials:

C₃₁H₂₄N₄O₉

xanthosine

Refernces