Ketobemidone hydrobromide

Base Information

• Chemical Name: Ketobemidone hydrobromide
• CAS No.: 73737-18-5
• Molecular Formula: BrH*C₁₅H₂₁NO₂
• Molecular Weight: 0
• Mol file: 73737-18-5.mol

Synonyms:Ketobemidone hydrobromide

Chemical Property of Ketobemidone hydrobromide

Chemical Property:

Purity/Quality:

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Technology Process of Ketobemidone hydrobromide

There total 1 articles about Ketobemidone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-4-(m-methoxyphenyl)-4-cyanopiperidine (5460-79-7) + ethylmagnesium bromide (925-90-6) → ketobemidone hydrobromide (73737-18-5)

Guidance literature:

With hydrogen bromide; Yield given. Multistep reaction; 1.) 40 deg C, 5000 bar, 4 h, 2.) reflux, 1 h;

DOI:10.1007/BF01172289

Reference yield: 38.0%

ketobemidone hydrobromide (73737-18-5) → 4-(3-hydroxyphenyl)-4-(1-hydroxypropyl)-1-methylpiperidine (73737-12-9)

Guidance literature:

With potassium hydroxide; sodium tetrahydroborate; In ethanol; water; at 80 ℃; for 2h;

DOI:10.1021/jm00180a024

upstream raw materials:

1-methyl-4-(m-methoxyphenyl)-4-cyanopiperidine

ethylmagnesium bromide

Downstream raw materials:

4-(3-hydroxyphenyl)-4-(1-hydroxypropyl)-1-methylpiperidine

Refernces