N-(4-aminophenyl)-4-tert-butylbenzamide

Base Information

• Chemical Name: N-(4-aminophenyl)-4-tert-butylbenzamide
• CAS No.: 129488-55-7
• Molecular Formula: C17H20N2O
• Molecular Weight: 268.359
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60352214
• Wikidata: Q82129235
• Mol file: 129488-55-7.mol

Synonyms:N-(4-aminophenyl)-4-tert-butylbenzamide;129488-55-7;N-(4-aminophenyl)-4-(tert-butyl)benzamide;CBMicro_000750;Cambridge id 5847422;Oprea1_385457;SCHEMBL7300203;DTXSID60352214;VBKLQORCYTWUFQ-UHFFFAOYSA-N;SMSF0008454;BBL002644;STK029649;AKOS000108297;CB02360;VS-01142;BIM-0000922.P001;N-(4-Amino-phenyl)-4-tert-butyl-benzamide;BB 0245315;CS-0316549;SR-01000221747;N-(4-Aminophenyl)-4-(1,1-dimethylethyl)-benzamide;SR-01000221747-1

Chemical Property of N-(4-aminophenyl)-4-tert-butylbenzamide

Chemical Property:

• PSA: 55.12000
• LogP: 4.47280
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 268.157563266
• Heavy Atom Count: 20
• Complexity: 318

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Aminophenyl)-4-tert-butylbenzamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)N

Technology Process of N-(4-aminophenyl)-4-tert-butylbenzamide

There total 5 articles about N-(4-aminophenyl)-4-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,4-phenylenediamine (106-50-3) + p-tert-butyl benzoyl chloride (1710-98-1) → N-(4-aminophenyl)-4-(tert-butyl)benzamide (129488-55-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/acsinfecdis.7b00120

Reference yield: 70.0%

→ N-(4-aminophenyl)-4-(tert-butyl)benzamide (129488-55-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield: 55.0%

4-(tert-butyl)-N-(4-nitrophenyl)benzamide (129488-50-2) → N-(4-aminophenyl)-4-(tert-butyl)benzamide (129488-55-7)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In ethanol; at 85 ℃; for 2h;

DOI:10.1016/j.bmcl.2021.127788

upstream raw materials:

4-(tert-butyl)-N-(4-nitrophenyl)benzamide

1,4-phenylenediamine

p-tert-butyl benzoyl chloride

4-nitro-aniline

Downstream raw materials:

4-(tert-butyl)-N-(4-(phenylamino)phenyl)benzamide

N-(4-acetamidophenyl)-4-(tert-butyl)benzamide