4-CHLORO-2-METHYL-D-PHENYLALANINE

Base Information

• Chemical Name: 4-CHLORO-2-METHYL-D-PHENYLALANINE
• CAS No.: 853680-23-6
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.664
• Mol file: 853680-23-6.mol

Synonyms:4-CHLORO-2-METHYL-D-PHENYLALANINE;(2R)-2-AMINO-3-(4-CHLORO-2-METHYLPHENYL)PROPANOIC ACID

Chemical Property of 4-CHLORO-2-METHYL-D-PHENYLALANINE

Chemical Property:

• PSA: 63.32000
• LogP: 2.30310

Purity/Quality:

95% ^*data from raw suppliers

(2R)-2-AMINO-3-(4-CHLORO-2-METHYLPHENYL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-METHYL-D-PHENYLALANINE

There total 1 articles about 4-CHLORO-2-METHYL-D-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(benzhydrylidene-amino)-3-(4-chloro-2-methyl-phenyl)-propionic acid ethyl ester (947615-09-0) → 2-amino-3-(4-chloro-2-methyl-phenyl)-propionic acid (853680-23-6)

Guidance literature:

With hydrogenchloride; In water; at 75 ℃;

Reference yield: 80.0%

2-amino-3-(4-chloro-2-methyl-phenyl)-propionic acid (853680-23-6) + di-tert-butyl dicarbonate (24424-99-5) → 2-tert-butoxycarbonylamino-3-(4-chloro-2-methylphenyl)-propionic acid (853680-24-7,791625-57-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 3h;

Reference yield:

2-amino-3-(4-chloro-2-methyl-phenyl)-propionic acid (853680-23-6) → 2-amino-3-(4-chloro-2-methyl-phenyl)-1-(4-quinazolin-4-yl-piperazin-1-yl)-propan-1-one dihydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / 3 h / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

3: trifluoroacetic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

2-(benzhydrylidene-amino)-3-(4-chloro-2-methyl-phenyl)-propionic acid ethyl ester

Downstream raw materials:

2-tert-butoxycarbonylamino-3-(4-chloro-2-methylphenyl)-propionic acid

[1-(4-chloro-2-methylbenzyl)-2-oxo-2-(4-quinazolin-4-yl-piperazin-1-yl)-ethyl]-carbamic acid tert-butyl ester