SRI 62-834

Base Information

• Chemical Name: SRI 62-834
• CAS No.: 113201-37-9
• Molecular Formula: C₂₉H₆₀NO₆P
• Molecular Weight: 549.772
• Mol file: 113201-37-9.mol

Synonyms:Ethanaminium,2-[[hydroxy[[tetrahydro-2-[(octadecyloxy)methyl]-2-furanyl]methoxy]phosphinyl]oxy]-N,N,N-trimethyl-,inner salt, (?à)-;SRI 62-834

Chemical Property of SRI 62-834

Chemical Property:

• PSA: 86.86000
• LogP: 8.09170

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SRI 62-834

There total 7 articles about SRI 62-834 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetrahydro-2-<(octadecyloxy)methyl>-2-<(benzyloxy)methyl>furan → (R)-<2-<tetrahydrofuran-2-yl>methoxy>phosphinyl>oxy>ethyl>-N,N,N-trimethylaminium hydroxide inner salt (113201-37-9,140147-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 2534.03 Torr

2: 1.) POCl₃, Et₃N, 2.) pyridine, H₂O / 1.) THF, r.t., 2 h, 2.) 50 deg C, 5 h; 55 deg C, 5 h

With pyridine; water; hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00128a052

Reference yield:

Tetrahydro-2-<(octadecyloxy)methyl>-2-<(benzyloxy)methyl>furan → (S)-<2-<tetrahydrofuran-2-yl>methoxy>phosphinyl>oxy>ethyl>-N,N,N-trimethylaminium hydroxide inner salt (113201-37-9,140147-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 2534.03 Torr

2: 1.) POCl₃, Et₃N, 2.) pyridine, H₂O / 1.) THF, r.t., 2 h, 2.) 50 deg C, 5 h; 55 deg C, 5 h

With pyridine; water; hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00128a052

Reference yield:

Tetrahydro-2-<(octadecyloxy)metyl>-2-<(trityloxy)methyl>furan → (R)-<2-<tetrahydrofuran-2-yl>methoxy>phosphinyl>oxy>ethyl>-N,N,N-trimethylaminium hydroxide inner salt (113201-37-9,140147-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / aq. TFA / CH₂Cl₂ / Ambient temperature

2: 1.) POCl₃, Et₃N, 2.) pyridine, H₂O / 1.) THF, r.t., 2 h, 2.) 50 deg C, 5 h; 55 deg C, 5 h

With pyridine; water; triethylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane;

DOI:10.1021/jo00128a052

upstream raw materials:

choline tosylate

(R)-Tetrahydro-2-<(octadecyloxy)metyl>-2-furanmethanol

(S)-Tetrahydro-2-<(octadecyloxy)metyl>-2-furanmethanol

Refernces