(S)-3-Methylpiperidine hydrochloride

Base Information

• Chemical Name: (S)-3-Methylpiperidine hydrochloride
• CAS No.: 155797-02-7
• Molecular Formula: C6H14ClN
• Molecular Weight: 135.63506
• Mol file: 155797-02-7.mol

Synonyms:(S)-3-Methylpiperidine hydrochloride

Chemical Property of (S)-3-Methylpiperidine hydrochloride

Chemical Property:

• Melting Point: 193.1-193.3 °C
• PSA: 12.03000
• LogP: 2.13670
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Methylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-Methylpiperidine hydrochloride

There total 11 articles about (S)-3-Methylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-picoline-N-oxide (1003-73-2) → 3-methylpiperidinehydrochloride (58531-29-6,155797-02-7)

Guidance literature:

3-picoline-N-oxide; With ammonium formate; 10percent palladium on carbon; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1021/jo015649g

Reference yield: 97.0%

(R(S),R)-N-tert-butanesulfinyl-3-methylpiperidine (1258939-82-0) → (3R)-3-methylpiperidine hydrochloride (155797-02-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; optical yield given as %ee;

DOI:10.1021/jo1020807

Reference yield: 91.0%

2-methylglutaronitrile (4553-62-2) → 3-methylpiperidinehydrochloride (58531-29-6,155797-02-7)

Guidance literature:

2-methylglutaronitrile; With C₄₆H₁₇₈O₄₁Si₄₂; titanium(IV)isopropoxide; In toluene; at 100 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In toluene; at 20 ℃; for 4h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2013.11.101

upstream raw materials:

1,2-dimethyl-3-(3-methylpiperidino)-5-phenylpyrazolium chloride

3-Methylpiperidine

3-picoline-N-oxide

2-methylcadaverine