3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one

Base Information

Chemical Name:3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one
CAS No.:549501-15-7
Molecular Formula:C₁₅H₉FO₃
Molecular Weight:256.233
Hs Code.:
Mol file:549501-15-7.mol

Synonyms:3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one;3-(4-fluorophenyl)-7-hydroxy-2-chromenone;3-(4-fluorophenyl)-7-hydroxy-chromen-2-one;3-(4-fluorophenyl)-7-hydroxychromen-2-one;3-(4-fluorophenyl)-7-hydroxy-coumarin

Suppliers and Price of 3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one
500mg
$ 183.00

Crysdot
3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one 95+%
5g
$ 752.00

Chemenu
3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one 95%
5g
$ 711.00

American Custom Chemicals Corporation
3-(4-FLUOROPHENYL)-7-HYDROXY-2H-CHROMEN-2-ONE 95.00%
5MG
$ 499.46

AK Scientific
3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one
500mg
$ 297.00

Total 3 raw suppliers

Chemical Property of 3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one

Chemical Property:

PSA：50.44000
LogP:3.30470

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one

There total 3 articles about 3-(4-Fluorophenyl)-7-hydroxy-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129742-35-4
4-[(tert-butyldimethylsilyl)oxy]-2-hydroxybenzaldehyde

: 549501-15-7
3-(4-fluorophenyl)-7-hydroxy-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c01160

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 549501-15-7
3-(4-fluorophenyl)-7-hydroxy-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfur; toluene-4-sulfonic acid; morpholine / 120 °C

1.2: 4 h / 100 °C

2.1: triethylamine; acetic anhydride / 1.17 h / 112 °C / Microwave irradiation; Green chemistry

2.2: 3 h / 80 °C / Green chemistry

With morpholine; acetic anhydride; toluene-4-sulfonic acid; sulfur; triethylamine;
DOI:10.1080/14756366.2018.1518958

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 549501-15-7
3-(4-fluorophenyl)-7-hydroxy-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 180 °C

2: 53 percent / Acid hydrolysis

With triethylamine; 1: Perkin-Oglialoro condensation;