Chemical Property of 1-Ethyl-2-benzimidazolinone
Chemical Property:
- Melting Point:118-120 °C(Solv: ethyl acetate (141-78-6))
- PKA:12.29±0.30(Predicted)
- PSA：37.79000
- Density:1.161g/cm3
- LogP:1.34950
- Storage Temp.:Store at RT
- Solubility.:DMSO: ≥20mg/mL
- XLogP3:1.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:1
- Exact Mass:162.079312947
- Heavy Atom Count:12
- Complexity:193
- Purity/Quality:
-
99%, *data from raw suppliers
1-EBIO *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCN1C2=CC=CC=C2NC1=O
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Description
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
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Uses
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
