6-fluoro-1H-indole-5-carboxylic Acid

Base Information

Chemical Name:6-fluoro-1H-indole-5-carboxylic Acid
CAS No.:908600-73-7
Molecular Formula:C₉H₆FNO₂
Molecular Weight:179.151
Hs Code.:
European Community (EC) Number:823-181-5
Nikkaji Number:J2.345.482C
Mol file:908600-73-7.mol

Synonyms:6-fluoro-1H-indole-5-carboxylic Acid;908600-73-7;1H-INDOLE-5-CARBOXYLIC ACID,6-FLUORO;SCHEMBL12616230;6-Fluoroindole-5-carboxylic Acid;MDHOVFSMMFAXIY-UHFFFAOYSA-N;MFCD12924426;6-fluoro-1H-indole-5-carboxylicAcid;AKOS023839234;AS-62867;CS-0060714;FT-0714460;1H-INDOLE-5-CARBOXYLIC ACID,6-FLUORO-;EN300-215307;W17101;A936600

Suppliers and Price of 6-fluoro-1H-indole-5-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
1H-INDOLE-5-CARBOXYLICACID,6-FLUORO 95
1g
$ 308.00

AccelPharmtech
6-fluoro-1H-Indole-5-carboxylicacid 97.00%
1G
$ 1890.00

Total 3 raw suppliers

Chemical Property of 6-fluoro-1H-indole-5-carboxylic Acid

Chemical Property:

PSA：53.09000
LogP:2.00520
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:179.03825660
Heavy Atom Count:13
Complexity:222

Purity/Quality:

95% purity ^*data from raw suppliers

1H-INDOLE-5-CARBOXYLICACID,6-FLUORO 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC2=CC(=C(C=C21)C(=O)O)F

Technology Process of 6-fluoro-1H-indole-5-carboxylic Acid

There total 4 articles about 6-fluoro-1H-indole-5-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 908600-83-9
6-fluoro-1-(triisopropylsilyl)-1H-indole-5-carboxylic acid

: 908600-73-7
6-fluoroindole-5-carboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃;
DOI:10.1002/ejoc.200600118

Reference yield:

: 908600-87-3
6-fluoro-1-[tri(propan-2-yl)silyl]-1H-indole

: 908600-73-7
6-fluoroindole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec-butyllithium / cyclohexane; tetrahydrofuran / -75 °C

1.2: 79 percent / cyclohexane; tetrahydrofuran / cooling

2.1: 90 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 25 °C

With tetrabutyl ammonium fluoride; sec.-butyllithium; In tetrahydrofuran; cyclohexane;
DOI:10.1002/ejoc.200600118

Reference yield:

: 399-51-9
6-fluoro-1H-indole

: 908600-73-7
6-fluoroindole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 73 percent / BuLi / hexane; tetrahydrofuran / 25 °C

2.1: sec-butyllithium / cyclohexane; tetrahydrofuran / -75 °C

2.2: 79 percent / cyclohexane; tetrahydrofuran / cooling

3.1: 90 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 25 °C

With n-butyllithium; tetrabutyl ammonium fluoride; sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane;
DOI:10.1002/ejoc.200600118