O-[(Guanin-9-yl)Methyl] Acyclovir

Base Information

• Chemical Name: O-[(Guanin-9-yl)Methyl] Acyclovir
• CAS No.: 166762-90-9
• Molecular Formula: C₁₄H₁₆N₁₀O₄
• Molecular Weight: 388.346
• Mol file: 166762-90-9.mol

Synonyms:O-[(Guanin-9-yl)Methyl] Acyclovir;Acyclovir Impurity J: 9,9'-[Ethylene-bis(oxymethylene)] Bis (2-amino-1-9-dihydro-6H-purin-6-one)

Chemical Property of O-[(Guanin-9-yl)Methyl] Acyclovir

Chemical Property:

• PKA: 9.04±0.20(Predicted)
• PSA: 199.62000
• Density: 1.99±0.1 g/cm3(Predicted)
• LogP: -0.94980
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly, Heated)

Purity/Quality:

99.90% ^*data from raw suppliers

O-[(Guanin-9-yl)methyl]Acyclovir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-(Guanin-9-yl)methyl Acyclovir is a dimer impurity of the antiviral agent Acyclovir (A192400). O-(Guanin-9-yl)methyl Acyclovir (Aciclovir EP Impurity J) is a dimer impurity of the antiviral agent Acyclovir (A192400).

Technology Process of O-[(Guanin-9-yl)Methyl] Acyclovir

There total 1 articles about O-[(Guanin-9-yl)Methyl] Acyclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-{9-[2-(2-acetylamino-6-oxo-1,6-dihydropurin-9-ylmethoxy)-ethoxymethyl]-6-oxo-6,9-dihydro-1H-purin-2-yl}acetamide (1417988-85-2) → 9,9'-[1,2-ethanediylbis(oxymethylene)]bis(2-amino-1,9-dihydro-6H-purin-6-one) (166762-90-9)

Guidance literature:

With ethanolamine; In water; for 10h; Reflux;

DOI:10.3390/molecules17088735

upstream raw materials:

N-{9-[2-(2-acetylamino-6-oxo-1,6-dihydropurin-9-ylmethoxy)-ethoxymethyl]-6-oxo-6,9-dihydro-1H-purin-2-yl}acetamide

Refernces