2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester

Base Information

• Chemical Name: 2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester
• CAS No.: 40800-98-4
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.296
• Mol file: 40800-98-4.mol

Synonyms:2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester

Chemical Property of 2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 449.7±40.0 °C(Predicted)
• PKA: 9.93±0.30(Predicted)
• PSA: 59.67000
• Density: 1.271±0.06 g/cm3(Predicted)
• LogP: 3.51580

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester

There total 3 articles about 2-[(2-Hydroxyphenyl)methyl]-3-benzofurancarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-hydroxy-phenyl)-1-(2-oxo-2,3-dihydro-benzofuran-3-yl)-ethanone (40800-91-7) → 2-o-Hydroxybenzyl-benzofuran-3-carboxylat (40800-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; aqueous hydrochloric acid

2: aqueous sodium carbonate-solution

With hydrogenchloride; sodium carbonate; acetic acid;

Reference yield:

2-salicyl-benzofuran-3-carboxylic acid (102469-60-3) + dimethyl sulfate (77-78-1) → 2-o-Hydroxybenzyl-benzofuran-3-carboxylat (40800-98-4)

Guidance literature:

With sodium carbonate;

Reference yield:

→ 2-o-Hydroxybenzyl-benzofuran-3-carboxylat (40800-98-4)

Guidance literature:

aus Verb. 17, Methanol//H2SO4;

upstream raw materials:

2-salicyl-benzofuran-3-carboxylic acid

dimethyl sulfate

2-(2-hydroxy-phenyl)-1-(2-oxo-2,3-dihydro-benzofuran-3-yl)-ethanone