2-chloro-6-(difluoroMethoxy)pyridine

Base Information

• Chemical Name: 2-chloro-6-(difluoroMethoxy)pyridine
• CAS No.: 1214377-45-3
• Molecular Formula: C6H4ClF2NO
• Molecular Weight: 179.5518664
• Hs Code.: 2933399990
• Mol file: 1214377-45-3.mol

Synonyms:2-chloro-6-(difluoroMethoxy)pyridine;2-Chloro-7-(difluoromethoxy)pyridine

Chemical Property of 2-chloro-6-(difluoroMethoxy)pyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.33640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-(difluoromethoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-(difluoroMethoxy)pyridine

There total 4 articles about 2-chloro-6-(difluoroMethoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-chloro-2-hydroxypyridine (16879-02-0) + trifluoromethanesulfonic acid difluoromethyl ether (1885-46-7) → 2-chloro-6-(difluoromethoxy)pyridine (1214377-45-3)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent;

DOI:10.1016/j.jfluchem.2017.08.006

Reference yield: 53.0%

6-chloro-2-hydroxypyridine (16879-02-0) + sodium chlorodifluoroacetate (1895-39-2) → 2-chloro-6-(difluoromethoxy)pyridine (1214377-45-3)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 55 ℃; for 18h;

Reference yield: 53.0%

6-chloro-2-pyridone (16879-02-0) + sodium chlorodifluoroacetate (1895-39-2) → 2-chloro-6-(difluoromethoxy)pyridine (1214377-45-3)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 55 ℃; for 18h;

DOI:10.1002/cmdc.201402555

upstream raw materials:

6-chloro-2-hydroxypyridine

sodium chlorodifluoroacetate

trifluoromethan

6-chloro-2-pyridone