(1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane

Base Information

Chemical Name:(1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane
CAS No.:303176-39-8
Molecular Formula:C11H13FO3
Molecular Weight:212.221
Hs Code.:
DSSTox Substance ID:DTXSID50461945
Nikkaji Number:J1.377.492G
Wikidata:Q82286403
Mol file:303176-39-8.mol

Synonyms:303176-39-8;(1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane;(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethane-1,2-diol;GCGMAEKAEXMJNG-KOLCDFICSA-N;SCHEMBL2256343;DTXSID50461945;(R)-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethane-1,2-diol

Suppliers and Price of (1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane
500 mg
$ 690.00

Biosynth Carbosynth
(1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane
500 mg
$ 840.00

Biosynth Carbosynth
(1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane
100 mg
$ 255.00

Total 14 raw suppliers

Chemical Property of (1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane

Chemical Property:

Boiling Point:384.8±37.0 °C(Predicted)
PKA:14.25±0.20(Predicted)
PSA：49.69000
Density:1.308±0.06 g/cm3(Predicted)
LogP:0.87250
Solubility.:Ethyl Acetate, Methanol
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:212.08487243
Heavy Atom Count:15
Complexity:212

Purity/Quality:

98% or more ^*data from raw suppliers

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1C(CO)O
Isomeric SMILES:C1CC2=C(C=CC(=C2)F)O[C@@H]1[C@@H](CO)O
Uses (+)-Nebivolol intermediate.

Technology Process of (1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane

There total 31 articles about (1'R,2S)-2-(1',2'-Dihydroxyethyl)-6-fluorochromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 303176-38-7
5-(5-fluoro-2-hydroxy-phenyl)-E-2-penten-1-ol

: 303176-39-8
1-[6-fluoro-(2S)-3,4-dihydro-2H-benzopyran-2-yl]-(1R)-1,2-ethylene glycol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; at -20 ℃; for 4h;
DOI:10.1016/S0040-4020(00)00572-X