DL-LYSINE-4,4,5,5-D4 2HCL

Base Information

• Chemical Name: DL-LYSINE-4,4,5,5-D4 2HCL
• CAS No.: 284664-88-6
• Molecular Formula: C₆H₁₄N₂O₂*2ClH
• Molecular Weight: 223.079
• Mol file: 284664-88-6.mol

Synonyms:DL-LYSINE-4,4,5,5-D4 DIHYDROCHLORIDE, 98 ATOM % D;DL-LYSINE-4,4,5,5-D4 2HCL 99.1 G;99.1g;CICC1126;(2S)-2,6-bis(azanyl)hexanoic acid dihydrochloride

Chemical Property of DL-LYSINE-4,4,5,5-D4 2HCL

Chemical Property:

• Vapor Pressure: 1.75E-06mmHg at 25°C
• Melting Point: 190 °C(lit.)
• Boiling Point: 369.8°C at 760 mmHg
• Flash Point: 177.4°C
• PSA: 89.34000
• LogP: 2.53190

Purity/Quality:

98% by CP; 96% atom D ^*data from raw suppliers

DL-Lysine-4,4,5,5-d4 dihydrochloride 98 atom % D ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: DL-Lysine-4,4,5,5-d4 2HCl (CAS# 284664-88-6) is a useful isotopically labeled research compound.

Technology Process of DL-LYSINE-4,4,5,5-D4 2HCL

There total 6 articles about DL-LYSINE-4,4,5,5-D4 2HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl N2,N6-bis(tert-butoxycarbonyl)-4,4,5,5-d4-(S)-lysinate → 4,4,5,5-d4-(S)-lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

methyl N²,N⁶-bis(tert-butoxycarbonyl)-4,4,5,5-d₄-(S)-lysinate; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

With hydrogenchloride; In ethyl acetate; for 4h;

DOI:10.1055/s-0037-1610221

Reference yield: 85.0%

N-benzoyl[3,3,4,4,5,5-2H6]lysine → [3,3,4,4,5,5-2H6]lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

Reference yield:

C6H7(2)H6NO2 → [3,3,4,4,5,5-2H6]lysine dihydrochloride (284664-88-6,284664-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / 1 h / Ambient temperature

2: 65 percent / PBr₃, Br₂ / 0.17 h / 100 °C

3: 66 percent / 28percent aq. NH₄OH / 0.5 h / Heating

4: 85 percent / aq. HCl / 10 h / Heating

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; bromine; phosphorus tribromide;

upstream raw materials:

[3,3,4,4,5,5-2H6]-ε-caprolactam