Chemical Property of (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
Chemical Property:
- Boiling Point:567.0±60.0 °C(Predicted)
- PKA:2.09±0.12(Predicted)
- PSA：80.50000
- Density:1.29±0.1 g/cm3(Predicted)
- LogP:4.79500
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥10mg/mL
- XLogP3:4.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:375.10414797
- Heavy Atom Count:27
- Complexity:617
- Purity/Quality:
-
97% *data from raw suppliers
iCRT 14 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)N(C(=O)S3)C4=CC=CC=C4
- Isomeric SMILES:CC1=CC(=C(N1C2=CN=CC=C2)C)/C=C\3/C(=O)N(C(=O)S3)C4=CC=CC=C4
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Uses
A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.
