Finerenone (BAY 94-8862)

Base Information

Chemical Name:Finerenone (BAY 94-8862)
CAS No.:1050477-31-0
Molecular Formula:C21H22N4O3
Molecular Weight:378.431
Hs Code.:
Mol file:1050477-31-0.mol

Synonyms:Finerenone (BAY 94-8862)

Suppliers and Price of Finerenone (BAY 94-8862)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Finerenone >98%
1 g
$ 3900.00

ChemScene
Finerenone 99.75%
100mg
$ 3600.00

ChemScene
Finerenone 99.75%
50mg
$ 2400.00

ChemScene
Finerenone 99.75%
25mg
$ 1550.00

ChemScene
Finerenone 99.75%
10mg
$ 800.00

ChemScene
Finerenone 99.75%
5mg
$ 480.00

Total 71 raw suppliers

Chemical Property of Finerenone (BAY 94-8862)

Chemical Property:

Boiling Point:554.7±50.0 °C(Predicted)
PKA:14.76±0.40(Predicted)
PSA：111.25000
Density:1.29±0.1 g/cm3(Predicted)
LogP:4.27338

Purity/Quality:

99% ^*data from raw suppliers

Finerenone >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist.
Uses Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.

Technology Process of Finerenone (BAY 94-8862)

There total 50 articles about Finerenone (BAY 94-8862) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.07%

: finerenone (+)O,O-dibenzoyl-D-tartaric acid

: 1050477-31-0
BAY₉₄₈₈₆₂

Guidance literature:: With sodium phosphate; In ethanol; water; toluene; at 23 - 50 ℃; for 6h; pH=4 - 7.5; Temperature; pH-value;

Reference yield: 82.0%

: rac-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

: 1050477-31-0
BAY₉₄₈₈₆₂

Guidance literature:: With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In tetrahydrofuran; at 40 - 100 ℃; for 24h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.202011256