Technology Process of 6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLIC ACID, 1,2,3,4,5,7-HEXAHYDRO-3-OXO-, 1,1-DIMETHYLETHYL ESTER
There total 1 articles about 6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLIC ACID, 1,2,3,4,5,7-HEXAHYDRO-3-OXO-, 1,1-DIMETHYLETHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
ethanol;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h
2.2: 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 1 h / 160 °C / Microwave irradiation
4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h
2.2: 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 1 h / 160 °C / Microwave irradiation
With
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;