Vildagliptin IMpurity 2 (Mixture of DiastereoMers)

Base Information

Chemical Name:Vildagliptin IMpurity 2 (Mixture of DiastereoMers)
CAS No.:1036959-23-5
Molecular Formula:C24H33N5O3
Molecular Weight:439.558
Hs Code.:
Mol file:1036959-23-5.mol

Synonyms:Vildagliptin IMpurity 2 (Mixture of DiastereoMers);Vildagliptin IMpurity 2;Vildagliptin IMPURITY B;(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile;Vildagliptin Impurity 1

Suppliers and Price of Vildagliptin IMpurity 2 (Mixture of DiastereoMers)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,2''S)-1,1''-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile
2.5g
$ 2605.00

TRC
(2S,2''S)-1,1''-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile
1g
$ 1390.00

Medical Isotopes, Inc.
(2S,2??S)-1,1??-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile
1 g
$ 640.00

Total 13 raw suppliers

Chemical Property of Vildagliptin IMpurity 2 (Mixture of DiastereoMers)

Chemical Property:

Boiling Point:730.0±60.0 °C(Predicted)
PKA:14.99±0.40(Predicted)
PSA：111.67000
Density:1.33±0.1 g/cm3(Predicted)
LogP:1.27706
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(2S,2''S)-1,1''-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S,2'S)-1,1'-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile is an impurity of Vildagliptin which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4). (2S,2''S)-1,1''-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).

Technology Process of Vildagliptin IMpurity 2 (Mixture of DiastereoMers)

There total 3 articles about Vildagliptin IMpurity 2 (Mixture of DiastereoMers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 702-82-9
3-aminoadamantan-1-ol

: 207557-35-5
(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

: 1036959-23-5
(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile

: 274901-16-5,1044676-63-2
vildagliptin

Guidance literature:: With potassium carbonate; potassium iodide; In tetrahydrofuran; at 66 ℃; for 2 - 14h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1036959-23-5
(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile

: 274901-16-5,1044676-63-2
vildagliptin

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / 2 h / 30 - 40 °C

2.1: dicyclohexyl-carbodiimide / dichloromethane / 1.5 h

3.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 0 - 5 °C

4.1: potassium carbonate; potassium iodide / tetrahydrofuran / 20 °C

4.2: 3 h / 90 °C

With potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 23500-10-9
(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid

: 1036959-23-5
(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile

: 274901-16-5,1044676-63-2
vildagliptin

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 1.5 h

2.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 0 - 5 °C

3.1: potassium carbonate; potassium iodide / tetrahydrofuran / 20 °C

3.2: 3 h / 90 °C

With potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;