7-Bromo Epinastine

Base Information

• Chemical Name: 7-Bromo Epinastine
• CAS No.: 1217052-16-8
• Molecular Formula: C₁₆H₁₄BrN₃
• Molecular Weight: 328.211
• Mol file: 1217052-16-8.mol

Synonyms:7-Bromo Epinastine;3-AMino-7-broMo-9,13b-dihydro-1H-dibenz[c,f]iMidazo[1,5-a]azepine;7-BroMo-9,13b-dihydro-1H-dibenz[c,f]iMidazo[1,5-a]azepin-3-aMine;Epinastine IMpurity B HBr

Chemical Property of 7-Bromo Epinastine

Chemical Property:

• PSA: 39.12000
• LogP: 3.93250

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

7-BromoEpinastine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Epinastine analogue.

Technology Process of 7-Bromo Epinastine

There total 2 articles about 7-Bromo Epinastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

epinastine (80012-43-7) → 3-amino-7-bromo-9,13-dihydro-1H-dibenzo[c,f]-imidazo[1,5-a]azepine (1217052-16-8)

Guidance literature:

With bromine; In chloroform; at 20 ℃; for 10h;

Reference yield:

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione (143878-20-0) → 3-amino-7-bromo-9,13-dihydro-1H-dibenzo[c,f]-imidazo[1,5-a]azepine (1217052-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 4 h / Reflux

2: dichloromethane / 4 h / 20 °C

3: bromine / chloroform / 10 h / 20 °C

With bromine; hydrazine hydrate; In methanol; dichloromethane; chloroform;

upstream raw materials:

2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione

epinastine

Refernces