ACETYLBACCATIN III, 7-(P)

Base Information

• Chemical Name: ACETYLBACCATIN III, 7-(P)
• CAS No.: 32981-90-1
• Molecular Formula: C33H40O12
• Molecular Weight: 628.673
• Mol file: 32981-90-1.mol

Synonyms:ACETYLBACCATIN III, 7-(P);BACCATIN III(P);7-Acety Baccatin III

Chemical Property of ACETYLBACCATIN III, 7-(P)

Chemical Property:

• PSA: 171.96000
• LogP: 2.22340

Purity/Quality:

98.5% ^*data from raw suppliers

7-ACETYLBACCATIN III 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETYLBACCATIN III, 7-(P)

There total 4 articles about ACETYLBACCATIN III, 7-(P) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetic anhydride (108-24-7) + baccatin III (27548-93-2) → 7-O-acetylbaccatine III (32981-90-1)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 23 ℃; Inert atmosphere;

DOI:10.1021/np900524d

Reference yield: 91.8%

10-deacetylbaccatin III (32981-86-5,172018-16-5) + acetic anhydride (108-24-7) → 7-O-acetylbaccatine III (32981-90-1)

Guidance literature:

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In tetrahydrofuran; at 10 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Concentration; Inert atmosphere;

Reference yield: 70.0%

7,13-diacetyl baccatin III (92950-44-2) → 7-O-acetylbaccatine III (32981-90-1)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -45 ℃; for 0.166667h;

upstream raw materials:

10-deacetylbaccatin III

acetic anhydride

baccatin III

7,13-diacetyl baccatin III

Downstream raw materials:

10-deacetylbaccatin III

7-O-acetyl-13-oxobaccatin III

2',7-bis-acetyltaxol

7-acetylpaclitaxel