Morinidazole

Base Information

Chemical Name:Morinidazole
CAS No.:92478-27-8
Molecular Formula:C₁₁H₁₈N₄O₄
Molecular Weight:270.288
Hs Code.:
UNII:TUPWG40JAL
ChEMBL ID:CHEMBL3884248
DSSTox Substance ID:DTXSID201031280
Metabolomics Workbench ID:155280
NCI Thesaurus Code:C184884
Nikkaji Number:J2.809.198B
Mol file:92478-27-8.mol

Synonyms:morinidazole

Suppliers and Price of Morinidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Morinidazole 98+%
10mg
$ 350.00

Crysdot
Morinidazole 98+%
5mg
$ 245.00

ChemScene
Morinidazole >98.0%
10mg
$ 600.00

ChemScene
Morinidazole >98.0%
5mg
$ 420.00

Total 35 raw suppliers

Chemical Property of Morinidazole

Chemical Property:

Boiling Point:521.4±50.0 °C(Predicted)
PKA:14.14±0.20(Predicted)
PSA：96.34000
Density:1.44±0.1 g/cm3(Predicted)
LogP:0.25390
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:270.13280507
Heavy Atom Count:19
Complexity:306

Purity/Quality:

99%, ^*data from raw suppliers

Morinidazole 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC=C(N1CC(CN2CCOCC2)O)[N+](=O)[O-]
Recent ClinicalTrials:A Trial to Assess the Efficacy and Safety of Morinidazole in Women With Pelvic Inflammatory Disease
Description Morinidazole (迈灵达?), discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.

Technology Process of Morinidazole

There total 3 articles about Morinidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 110-91-8,99108-56-2
morpholine

: 16773-52-7
(±)-2-methyl-5-nitro-1-(oxiran-2-ylmethyl)-1H-imidazole

: 92478-27-8
Morinidazole

Guidance literature:: In acetonitrile; at 80 ℃;
DOI:10.1016/j.ejmech.2016.09.006

Reference yield: 53.5%

: 110-91-8,99108-56-2
morpholine

: 16773-42-5,166734-83-4
ornidazole

: 92478-27-8
Morinidazole

Guidance literature:: With potassium carbonate; In ethanol; for 6h; Reflux;

Reference yield:

: 16773-42-5,166734-83-4
ornidazole

: 92478-27-8
Morinidazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane; water / 0 °C

2: acetonitrile / 80 °C

With sodium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2016.09.006