4-broMo-5-Methylpicolinaldehyde

Base Information

• Chemical Name: 4-broMo-5-Methylpicolinaldehyde
• CAS No.: 1196157-14-8
• Molecular Formula: C7H6BrNO
• Molecular Weight: 200.03264
• Hs Code.: 2933399090
• Mol file: 1196157-14-8.mol

Synonyms:4-broMo-5-Methylpicolinaldehyde;4-bromo-5-methylpyridine-2-carbaldehyde

Chemical Property of 4-broMo-5-Methylpicolinaldehyde

Chemical Property:

• Boiling Point: 268.0±35.0 °C(Predicted)
• PKA: 2.07±0.10(Predicted)
• PSA: 29.96000
• Density: 1.577±0.06 g/cm3(Predicted)
• LogP: 1.96500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-5-methylpicolinaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-?Bromo-?5-?methyl-?2-?pyridinecarbaldehyde is a reagent used in the preparation of voltage-gated sodium channel modulators for therapy.

Technology Process of 4-broMo-5-Methylpicolinaldehyde

There total 6 articles about 4-broMo-5-Methylpicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-bromo-5-methylpyridin-2-yl)methanol (820224-83-7) → 4-bromo-5-methylpyridine-2-carbaldehyde (1196157-14-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

Reference yield:

2,5-dimethylpyridine (589-93-5) → 4-bromo-5-methylpyridine-2-carbaldehyde (1196157-14-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 - 20 °C

2: sulfuric acid; nitric acid / 73 h / 0 - 110 °C

3: acetic acid; Acetyl bromide / 4 h / 0 - 80 °C

4: 2 h / 110 °C / Inert atmosphere

5: hydrogenchloride / water / 2 h

6: manganese(IV) oxide / dichloromethane / 20 °C

With hydrogenchloride; manganese(IV) oxide; Acetyl bromide; sulfuric acid; nitric acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; water;

Reference yield:

2,5-dimethylpyridine N-oxide (4986-05-4) → 4-bromo-5-methylpyridine-2-carbaldehyde (1196157-14-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 73 h / 0 - 110 °C

2: acetic acid; Acetyl bromide / 4 h / 0 - 80 °C

3: 2 h / 110 °C / Inert atmosphere

4: hydrogenchloride / water / 2 h

5: manganese(IV) oxide / dichloromethane / 20 °C

With hydrogenchloride; manganese(IV) oxide; Acetyl bromide; sulfuric acid; nitric acid; acetic acid; In dichloromethane; water;

upstream raw materials:

2,5-dimethylpyridine

2,5-dimethylpyridine N-oxide

2,5-dimethyl-4-nitropyridine 1-oxide

2,5-dimethyl-4-bromopyridine N-oxide

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