N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide

Base Information

Chemical Name:N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide
CAS No.:664993-53-7
Molecular Formula:C25H26N2O5
Molecular Weight:434.48434
Hs Code.:
DSSTox Substance ID:DTXSID60387940
Wikidata:Q27166837
ChEMBL ID:CHEMBL3753077
Mol file:664993-53-7.mol

Synonyms:664993-53-7;jw55;JW 55;JW-55;N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide;N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide;CHEMBL3753077;N-(4-((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methylcarbamoyl)phenyl)furan-2-carboxamide;N-[4-({[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYL}CARBAMOYL)PHENYL]FURAN-2-CARBOXAMIDE;N-(4-(((4-(4-Methoxyphenyl)oxan-4- Yl)methyl)carbamoyl)phenyl)furan-2-Carboxamide;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW55 Inhibitor;N-[4-({[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)phenyl]furan-2-carboxamide;SCHEMBL1896657;CHEBI:95068;DTXSID60387940;EX-A274;HMS1591J12;HMS3426G05;BCP08451;BDBM50136777;MFCD03863265;s6745;STK774983;AKOS001733937;CS-1757;NCGC00379145-08;NCGC00379145-12;AC-35206;AS-16546;HY-13968;FT-0700348;A13731;SR-01000269072;SR-01000269072-1;Q27166837;N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide;N-{4-[4-(4-methoxyphenyl)tetrahydro-2h-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide;A95;N~2~-{4-[({[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}amino)carbonyl]phenyl}-2-furamide

Suppliers and Price of N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
JW 55
10mg
$ 466.00

TRC
JW-55
10mg
$ 155.00

TRC
JW-55
100mg
$ 1230.00

Tocris
JW55 ≥98%(HPLC)
50
$ 863.00

Tocris
JW55 ≥98%(HPLC)
10
$ 215.00

Sigma-Aldrich
JW55 ≥98% (HPLC)
5mg
$ 100.00

Sigma-Aldrich
JW55 ≥98% (HPLC)
25mg
$ 404.00

Sigma-Aldrich
Tankyrase1/2 Inhibitor IV, JW55
25mg
$ 200.00

Medical Isotopes, Inc.
JW-55
10 mg
$ 640.00

Matrix Scientific
N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide 95%
10g
$ 7030.00

Total 27 raw suppliers

Chemical Property of N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide

Chemical Property:

Boiling Point:572.6±50.0 °C(Predicted)
PKA:12.41±0.70(Predicted)
PSA：93.29000
Density:1.235±0.06 g/cm3(Predicted)
LogP:4.79360
Storage Temp.:2-8°C
Solubility.:DMSO: soluble15mg/mL, clear
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:434.18417193
Heavy Atom Count:32
Complexity:620

Purity/Quality:

99%, ^*data from raw suppliers

JW 55 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CO4
Description JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.
Uses JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Technology Process of N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide

There total 7 articles about N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 440087-51-4
1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine

: C₁₂H₈ClNO₃

: 664993-53-7
N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide

Guidance literature:: With triethylamine; In 1,4-dioxane; at 15 ℃; Reflux;
DOI:10.1134/S1070363215050096

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 664993-53-7
N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 20 °C

2: trimethylaluminum / toluene / 2 h / Reflux

With trimethylaluminum; potassium carbonate; In dichloromethane; toluene;

Reference yield:

: 527-69-5
2-furancarbonyl chloride

: 664993-53-7
N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 20 °C

2: trimethylaluminum / toluene / 2 h / Reflux

With trimethylaluminum; potassium carbonate; In dichloromethane; toluene;