2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl)

Base Information

• Chemical Name: 2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl)
• CAS No.: 30194-68-4
• Molecular Formula: C₁₀H₁₇N₅
• Molecular Weight: 207.278
• Hs Code.: 2933990090
• Mol file: 30194-68-4.mol

Synonyms:2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl);2-(4-pyrimidin-2-ylpiperazin-1-yl)ethylamine;2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine

Chemical Property of 2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl)

Chemical Property:

• PSA: 58.28000
• LogP: 2.66650

Purity/Quality:

98%min ^*data from raw suppliers

[2-(4-Pyrimidin-2-ylpiperazin-1-yl)ethyl]aminetrihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl)

There total 7 articles about 2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanamine(SALTDATA: 3HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-(pyrimidin-2-yl)piperazin-1-yl)acetonitrile (33386-13-9) → 1-(pyrimidin-2-yl)-4-(2-aminoethyl)piperazine (30194-68-4)

Guidance literature:

With hydrogen; In methanol; for 12h; under 3102.97 Torr; Autoclave;

DOI:10.1016/j.bmc.2010.06.025

Reference yield:

2-(2-bromoethyl)isoindoline-1,3-dione (574-98-1) + N-(2-pyridinyl)piperazine (20980-22-7) → 1-(pyrimidin-2-yl)-4-(2-aminoethyl)piperazine (30194-68-4)

Guidance literature:

With potassium carbonate; In hydrazine hydrate; N,N-dimethyl-formamide;

Reference yield:

2-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione (95847-91-9) → 1-(pyrimidin-2-yl)-4-(2-aminoethyl)piperazine (30194-68-4)

Guidance literature:

With hydrazine; In ethanol; at 70 ℃; for 5h;

DOI:10.1016/j.bmc.2004.06.011

upstream raw materials:

2-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

N-(2-pyridinyl)piperazine

2-(2-bromoethyl)isoindoline-1,3-dione

2-(4-(pyrimidin-2-yl)piperazin-1-yl)acetonitrile