1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE

Base Information

• Chemical Name: 1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE
• CAS No.: 883526-76-9
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933990090
• Mol file: 883526-76-9.mol

Synonyms:1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE;1,5-dimethyl-1H-indole-2-carbaldehyde(SALTDATA: FREE)

Chemical Property of 1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 336.424°C at 760 mmHg
• Flash Point: 157.264°C
• PSA: 22.00000
• Density: 1.09g/cm³
• LogP: 2.29920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1,5-dimethyl-1H-indole-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE

There total 8 articles about 1,5-DIMETHYL-1H-INDOLE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,5-dimethyl-1H-indole (27816-53-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1,5-dimethyl-1H-indole-2-carbaldehyde (883526-76-9)

Guidance literature:

1,5-dimethyl-1H-indole; With n-butyllithium; In diethyl ether; for 3h; Reflux; Inert atmosphere;

N,N-dimethyl-formamide; In diethyl ether; for 5h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.5b01223

Reference yield:

C11H13NO (943117-52-0) → 1,5-dimethyl-1H-indole-2-carbaldehyde (883526-76-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 12h; Reflux;

DOI:10.1055/s-0030-1259537

Reference yield:

ethyl 1,5-dimethyl-indole-2-carboxylate (67929-99-1) → 1,5-dimethyl-1H-indole-2-carbaldehyde (883526-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201502553

upstream raw materials:

C₁₁H₁₃NO

methyl-1,5-dimethyl-1H-indole-2-carboxylate

5-methylindole-2-carboxylic acid

5-methylindole-2-carboxylic acid methyl ester

Downstream raw materials:

C₂₁H₁₉N