Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI)

Base Information

• Chemical Name: Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI)
• CAS No.: 129222-17-9
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Mol file: 129222-17-9.mol

Synonyms:Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI)

Chemical Property of Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI)

Chemical Property:

• PSA: 37.38000
• LogP: 0.30180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI)

There total 3 articles about Cyclopenta[c]pyrrol-5(1H)-one, 2-acetyl-2,3,3a,4-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allylpropargylamine (42268-68-8) → 2-Acetyl-2,3,3a,4-tetrahydro-1H-cyclopenta[c]pyrrol-5-one (129222-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Et₃N / diethyl ether

2: 2.) silica gel, O₂ / 1.) Et₂O, r.t., 14-18 h, 2.) 70 deg C, 2.5 h

With oxygen; silica gel; triethylamine; In diethyl ether;

DOI:10.1016/S0040-4039(00)60352-0

Reference yield:

N-Acetyl-N-allyl-N-propynylamine (129222-21-5) → 2-acetyl-hexahydro-cyclopenta[c]pyrrol-5-one (129222-15-7) + 2-Acetyl-2,3,3a,4-tetrahydro-1H-cyclopenta[c]pyrrol-5-one (129222-17-9)

Guidance literature:

With oxygen; silica gel; Yield given. Multistep reaction. Yields of byproduct given; 1.) Et₂O, r.t., 14-18 h, 2.) 70 deg C, 2.5 h;

DOI:10.1016/S0040-4039(00)60352-0

Reference yield:

N-Acetyl-N-allyl-N-propynylamine (129222-21-5) → 2-acetyl-hexahydro-cyclopenta[c]pyrrol-5-one (129222-15-7) + 2-Acetyl-2,3,3a,4-tetrahydro-1H-cyclopenta[c]pyrrol-5-one (129222-17-9)

Guidance literature:

With dicobalt octacarbonyl; Yield given. Multistep reaction; 1) Et₂O, 6h, r.t. 2) CCl₄, 50 deg C, 18h, irradiation;

upstream raw materials:

N-Acetyl-N-allyl-N-propynylamine

allylpropargylamine