DESTHIAZOLYLMETHYL RITONAVIR

Base Information

• Chemical Name: DESTHIAZOLYLMETHYL RITONAVIR
• CAS No.: 256328-82-2
• Molecular Formula: C33H43N5O4S
• Molecular Weight: 605.802
• Mol file: 256328-82-2.mol

Synonyms:DESTHIAZOLYLMETHYL RITONAVIR;(2S)-3-Methyl-2-[[[Methyl[[2-(1-Methylethyl)-4-thiazolyl]Methyl]aMino]carbonyl]aMino]-N-[(1S)-1-[[(4S,5S)-2-oxo-4-(phenylMethyl)-5-oxazolidinyl]Methyl]-2-phenylethyl]-butanaMide

Chemical Property of DESTHIAZOLYLMETHYL RITONAVIR

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 65-69°C
• Boiling Point: 874.007°C at 760 mmHg
• PKA: 12.40±0.46(Predicted)
• Flash Point: 482.382°C
• PSA: 140.90000
• Density: 1.185g/cm³
• LogP: 6.38040
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Desthiazolylmethyl Ritonavir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An analogue of the selective HIV protease inhibitor Ritonavir (R535000). Desthiazolylmethyl Ritonavir (Ritonavir EP Impurity L) is an analogue of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.

Technology Process of DESTHIAZOLYLMETHYL RITONAVIR

There total 2 articles about DESTHIAZOLYLMETHYL RITONAVIR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5S)-5-((2S)-2-amino-3-phenyl-propyl)-4-benzyl-1,3-oxazolidin-2-one (256328-86-6) + N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine (154212-61-0) → (2S)-N-(((1S)-1-benzyl-2-((4S,5S)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl)ethyl)-2-((((2-isopropyl-1,3-thiazol-4-yl)methyl)N-methyl-amino)carbonyl)amino)-3-methylbutanamide (256328-82-2)

Guidance literature:

(4S,5S)-5-((2S)-2-amino-3-phenyl-propyl)-4-benzyl-1,3-oxazolidin-2-one; N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 22 ℃; for 4h;

With citric acid; In tetrahydrofuran; water; for 0.5h;

Reference yield:

ritonavir (155213-67-5) → (2S)-N-(((1S)-1-benzyl-2-((4S,5S)-4-benzyl-2-oxo-1,3-oxazolidin-5-yl)ethyl)-2-((((2-isopropyl-1,3-thiazol-4-yl)methyl)N-methyl-amino)carbonyl)amino)-3-methylbutanamide (256328-82-2)

Guidance literature:

With potassium tert-butylate; oxygen; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2016.10.022

upstream raw materials:

(4S,5S)-5-((2S)-2-amino-3-phenyl-propyl)-4-benzyl-1,3-oxazolidin-2-one

N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine

ritonavir