Technology Process of 10-Methylthioethyl estra-4,9(11)-diene 3,17-dione
There total 5 articles about 10-Methylthioethyl estra-4,9(11)-diene 3,17-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol;
for 1h;
Yield given;
Heating;
DOI:10.1021/jm950539l
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71.6 percent / 1,2-dichloro-ethane / 8 h / Heating
2: 85.5 percent / lithium aluminum hydride / tetrahydrofuran / 1.) -50 deg C, 30 min, 2.) RT, 2 h
3: 100 percent / triethylamine / CH2Cl2 / 0.75 h / 0 °C
4: dimethylformamide / 1 h / 35 °C
5: 6 N hydrochloric acid / ethanol / 1 h / Heating
With
hydrogenchloride; lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950539l
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / triethylamine / CH2Cl2 / 0.75 h / 0 °C
2: dimethylformamide / 1 h / 35 °C
3: 6 N hydrochloric acid / ethanol / 1 h / Heating
With
hydrogenchloride; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950539l
