3-aMino-5-fluoro-2-Methoxybenzoic acid

Base Information

• Chemical Name: 3-aMino-5-fluoro-2-Methoxybenzoic acid
• CAS No.: 151793-23-6
• Molecular Formula: C8H8FNO3
• Molecular Weight: 185.1524232
• Mol file: 151793-23-6.mol

Synonyms:3-aMino-5-fluoro-2-Methoxybenzoic acid

Chemical Property of 3-aMino-5-fluoro-2-Methoxybenzoic acid

Chemical Property:

• PSA: 72.55000
• LogP: 1.69590
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

3-Amino-5-fluoro-2-methoxy-benzoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-aMino-5-fluoro-2-Methoxybenzoic acid

There total 3 articles about 3-aMino-5-fluoro-2-Methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-fluoro-2-methoxy-3-nitrobenzoic acid (151793-22-5) → 3-amino-5-fluoro-2-methoxybenzoic acid (151793-23-6)

Guidance literature:

With hydrogen; Ni-Raney; In ethanol; for 1h; Ambient temperature;

DOI:10.1016/0223-5234(93)90129-3

Reference yield:

methyl 5-fluoro-2-methoxybenzoate (151793-20-3) → 3-amino-5-fluoro-2-methoxybenzoic acid (151793-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / HNO₃, H₂SO₄ / -5 °C

2: 82 percent / 6percent aq. NaOH / ethanol / 0.17 h / Heating

3: 71 percent / H₂ / Ni-Raney / ethanol / 1 h / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; nitric acid; Ni-Raney; In ethanol;

DOI:10.1016/0223-5234(93)90129-3

Reference yield:

methyl 5-fluoro-2-methoxy-3-nitrobenzoate (151793-21-4) → 3-amino-5-fluoro-2-methoxybenzoic acid (151793-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 6percent aq. NaOH / ethanol / 0.17 h / Heating

2: 71 percent / H₂ / Ni-Raney / ethanol / 1 h / Ambient temperature

With sodium hydroxide; hydrogen; Ni-Raney; In ethanol;

DOI:10.1016/0223-5234(93)90129-3

upstream raw materials:

5-fluoro-2-methoxy-3-nitrobenzoic acid

methyl 5-fluoro-2-methoxybenzoate

methyl 5-fluoro-2-methoxy-3-nitrobenzoate

Downstream raw materials:

3-Amino-N-(2-diethylamino-ethyl)-5-fluoro-2-methoxy-benzamide