4'-CYANO-4-BIPHENYLSULFONIC ACID

Base Information

• Chemical Name: 4'-CYANO-4-BIPHENYLSULFONIC ACID
• CAS No.: 780010-15-3
• Molecular Formula: C₁₃H₉NO₃S
• Molecular Weight: 259.285
• Mol file: 780010-15-3.mol

Synonyms:4'-CYANO-4-BIPHENYLSULFONIC ACID

Chemical Property of 4'-CYANO-4-BIPHENYLSULFONIC ACID

Chemical Property:

• PSA: 86.54000
• LogP: 3.55278

Purity/Quality:

99%min ^*data from raw suppliers

4'-CYANO-4-BIPHENYLSULFONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-CYANO-4-BIPHENYLSULFONIC ACID

There total 1 articles about 4'-CYANO-4-BIPHENYLSULFONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyano-1,1'-biphenyl (2920-38-9) → 4'-cyano[1,1'-biphenyl]-4-sulfonic acid (780010-15-3)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at 10 ℃;

DOI:10.1016/j.bmcl.2009.05.011

Reference yield:

4'-cyano[1,1'-biphenyl]-4-sulfonic acid (780010-15-3) → 4'-cyano-N-{1-methyl-1H-pyrrolo[2,3-b]pyridin-6-yl}[1,1'-biphenyl]-4-sulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 16 h / Reflux

2: pyridine / 3 h / 20 °C

With pyridine; trichlorophosphate;

Reference yield:

4'-cyano[1,1'-biphenyl]-4-sulfonic acid (780010-15-3) → 4'-cyano-N-{4-methyl-1H-pyrrolo[2,3-b]pyridin-6-yl}-[1,1'-biphenyl]-4-sulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 16 h / Reflux

2: pyridine / 20 °C

With pyridine; trichlorophosphate;

upstream raw materials:

4-cyano-1,1'-biphenyl

Refernces

• 1、 Siu, Michael,Johnson, Theodore O.,Wang, Yong,Nair, Sajiv K.,Taylor, Wendy D.,Cripps, Stephan J.,Matthews, Jean J.,Edwards, Martin P.,Pauly, Thomas A.,Ermolieff, Jacques,Castro, Arturo,Hosea, Natilie A.,LaPaglia, Amy,Fanjul, Andrea N.,Vogel, Jennifer E.. "N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275". scheme or table. p. 3493 - 3497. Retrieved 2010/04/05.