2-amino-N-(2,4-dimethylphenyl)benzamide

Base Information

• Chemical Name: 2-amino-N-(2,4-dimethylphenyl)benzamide
• CAS No.: 21132-02-5
• Molecular Formula: C15H16N2O
• Molecular Weight: 240.305
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID30383898
• Wikidata: Q82175708
• ChEMBL ID: CHEMBL39257
• Mol file: 21132-02-5.mol

Synonyms:2-amino-N-(2,4-dimethylphenyl)benzamide;21132-02-5;Benzamide, 2-amino-N-(2,4-dimethylphenyl)-;Oprea1_368090;CHEMBL39257;SCHEMBL1962893;DTXSID30383898;MFCD00115976;STK292549;AKOS000126448;BS-35850;CS-0359051;Z56040685

Chemical Property of 2-amino-N-(2,4-dimethylphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.000119mmHg at 25°C
• Boiling Point: 335.5°C at 760 mmHg
• Flash Point: 156.7°C
• PSA: 55.12000
• Density: 1.182g/cm³
• LogP: 3.79210
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 240.126263138
• Heavy Atom Count: 18
• Complexity: 292

Purity/Quality:

99% ^*data from raw suppliers

2-amino-N-(2,4-dimethylphenyl)benzamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2N)C

Technology Process of 2-amino-N-(2,4-dimethylphenyl)benzamide

There total 7 articles about 2-amino-N-(2,4-dimethylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-nitro-benzoic acid-(2,4-dimethyl-anilide) (102630-95-5) → 2-amino-N-(2,4-dimethylphenyl)benzamide (21132-02-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 3h; under 2327.2 Torr;

DOI:10.1021/jm00158a038

Reference yield: 55.91%

2,4-Xylidine (95-68-1) + 2-aminobenzoyl chloride (21563-73-5) → 2-amino-N-(2,4-dimethylphenyl)benzamide (21132-02-5)

Guidance literature:

In diethyl ether; at 0 - 10 ℃; for 0.5h;

DOI:10.1007/s00044-010-9537-5

Reference yield:

isatoic anhydride (118-48-9) + 2,4-Xylidine (95-68-1) → 2-amino-N-(2,4-dimethylphenyl)benzamide (21132-02-5)

Guidance literature:

upstream raw materials:

isatoic anhydride

2,4-Xylidine

2-nitro-benzoic acid-(2,4-dimethyl-anilide)

2-nitrobenzyl chloride

Downstream raw materials:

3-(2,4-dimethylphenyl)-2-methylquinazolin-4(3H)-one

3-(2,4-dimethylphenyl)-4-(3H)quinazolinone

2-(2,4-Dimethyl-anilinomethyl)-anilin