K 02288

Base Information

• Chemical Name: K 02288
• CAS No.: 1431985-92-0
• Molecular Formula: C20H20N2O4
• Molecular Weight: 352.38
• Mol file: 1431985-92-0.mol

Synonyms:K 02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-;K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;LM-3151 K02288;K 02288(K 02288a);K 02288a

Chemical Property of K 02288

Chemical Property:

• Boiling Point: 522.2±50.0 °C(Predicted)
• PKA: 9.33±0.10(Predicted)
• PSA: 86.83000
• Density: 1.232±0.06 g/cm3(Predicted)
• LogP: 4.31040
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

K 02288 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, K 02288 can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.
• Uses: K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.