4-Bromo-6-tert-butylpyrimidine

Base Information

• Chemical Name: 4-Bromo-6-tert-butylpyrimidine
• CAS No.: 19136-36-8
• Molecular Formula: C8H11BrN2
• Molecular Weight: 215.09034
• DSSTox Substance ID: DTXSID20355786
• Wikidata: Q82134825
• Mol file: 19136-36-8.mol

Synonyms:4-bromo-6-tert-butylpyrimidine;19136-36-8;4-bromo-6-(tert-butyl)pyrimidine;SCHEMBL2877234;DTXSID20355786;AKOS015945632;FT-0717344;EN300-396300;F1967-4012;Z1269140806

Chemical Property of 4-Bromo-6-tert-butylpyrimidine

Chemical Property:

• PSA: 25.78000
• LogP: 2.53660
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 214.01056
• Heavy Atom Count: 11
• Complexity: 131

Purity/Quality:

98.5% ^*data from raw suppliers

4-BROMO-6-(TERT-BUTYL)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC(=NC=N1)Br

Technology Process of 4-Bromo-6-tert-butylpyrimidine

There total 1 articles about 4-Bromo-6-tert-butylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-hydroxy-6-tert-butylpyrimidine (3438-49-1) → 6-Brom-4-t-butyl-pyrimidin (19136-36-8)

Guidance literature:

With N,N-dimethyl-aniline; phosphorus(V) oxybromide; In benzene; for 3h; Heating / reflux;

upstream raw materials:

4-hydroxy-6-tert-butylpyrimidine

Refernces

• 1、 -. "METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS". Page/Page column 255. . Retrieved 2010/02/13.