1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester

Base Information

Chemical Name:1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester
CAS No.:1259393-27-5
Molecular Formula:C14H17NO3
Molecular Weight:247.28968
Hs Code.:
Mol file:1259393-27-5.mol

Synonyms:1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester;methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate;2,3,4,5-tetrahydro-7,9-dimethyl-5-oxo-1H-1-Benzazepine-1-carboxylic acid, methyl ester

Suppliers and Price of 1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,3,4,5-tetrahydro-7,9-dimethyl-5-oxo-1H-1-Benzazepine-1-carboxylicacidmethylester
100mg
$ 330.00

Total 14 raw suppliers

Chemical Property of 1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester

Chemical Property:

PSA：46.61000
LogP:2.91770

Purity/Quality:

98% ^*data from raw suppliers

2,3,4,5-tetrahydro-7,9-dimethyl-5-oxo-1H-1-Benzazepine-1-carboxylicacidmethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester

There total 9 articles about 1H-1-Benzazepine-1-carboxylic acid, 2,3,4,5-tetrahydro-7,9-diMethyl-5-oxo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: methyl (4-chloro-4-oxobutyl)(2,4-dimethylphenyl)carbamate

: 1259393-27-5
methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetra-hydro-1H-benzo[b]azepine-1-carboxylate

: dimethyl 1⁴,1⁶,7⁴,7⁶-tetramethyl-6,12-dioxo-2,8-diaza-1,7(1,3)-dibenzenacyclododecaphane-2,8-dicarboxylate

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 35 - 40 ℃; Reagent/catalyst; Solvent; Temperature; Concentration;
DOI:10.1055/s-0034-1378279

Reference yield:

: 1259393-30-0
4-[(2,4-dimethylphenyl)(methoxycarbonyl)amino]butanoic acid

: 1259393-27-5
methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetra-hydro-1H-benzo[b]azepine-1-carboxylate

Guidance literature:: With Aluminum(III) chloride hexahydrate; thionyl chloride; In methanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; at -5 - 45 ℃;

Reference yield:

: 95-68-1
2,4-Xylidine

: 1259393-27-5
methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetra-hydro-1H-benzo[b]azepine-1-carboxylate

: dimethyl 1⁴,1⁶,7⁴,7⁶-tetramethyl-6,12-dioxo-2,8-diaza-1,7(1,3)-dibenzenacyclododecaphane-2,8-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / toluene / 3 h / 85 °C

2: sodium carbonate / toluene / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium hydroxide; water / toluene; methanol / 3 h / 55 - 60 °C

4: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C

5: aluminum (III) chloride / dichloromethane / 5.5 h / 35 - 40 °C

With aluminum (III) chloride; thionyl chloride; water; sodium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane; toluene; 5: |Friedel-Crafts Acylation;
DOI:10.1055/s-0034-1378279