1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine

Base Information

• Chemical Name: 1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine
• CAS No.: 856843-58-8
• Molecular Formula: C₁₂H₂₅N₃
• Molecular Weight: 211.351
• DSSTox Substance ID: DTXSID30406778
• Mol file: 856843-58-8.mol

Synonyms:856843-58-8;1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine;1-Methyl-4-(2-(piperidin-2-yl)ethyl)piperazine;1-methyl-4-(2-piperidin-2-ylethyl)piperazine;1-methyl-4-[2-(piperidin-2-yl)ethyl]piperazine;MFCD00854097;1-methyl-4-[2-(2-piperidinyl)ethyl]piperazine;SCHEMBL18183309;DTXSID30406778;AKOS000270718;AKOS016040089;NS-02379;CS-0312938;FT-0722044;BRD-A58881627-001-01-2;F2185-0318;5-O-(4,4-DIMETHOXYTRITYL)-N4-BENZOYL-5-METHYL-2-DEOXYCYTIDINE

Chemical Property of 1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine

Chemical Property:

• Boiling Point: 128-130 °C(Press: 1 Torr)
• PKA: 10.50±0.10(Predicted)
• PSA: 18.51000
• Density: 0.940±0.06 g/cm3(Predicted)
• LogP: 0.97060
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 211.204847810
• Heavy Atom Count: 15
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

1-methyl-4-(2-(piperidin-2-yl)ethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCC2CCCCN2

Technology Process of 1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine

There total 3 articles about 1-Methyl-4-(2-piperidin-2-yl-ethyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(2-pyridyl)ethyl]-N'-methylpiperazine (90125-59-0) → 1-methyl-4-(2-[2]piperidyl-ethyl)-piperazine (856843-58-8)

Guidance literature:

With acetic acid; platinum; at 75 ℃; under 91938.4 Torr; Hydrogenation;

DOI:10.1021/ja01097a016

Reference yield:

1-methyl-piperazine (109-01-3) → 1-methyl-4-(2-[2]piperidyl-ethyl)-piperazine (856843-58-8)

Guidance literature:

Multi-step reaction with 2 steps

2: platinum; acetic acid / 75 °C / 91938.4 Torr / Hydrogenation

With acetic acid; platinum;

DOI:10.1021/ja01097a016

Reference yield:

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 1-methyl-4-(2-[2]piperidyl-ethyl)-piperazine (856843-58-8)

Guidance literature:

Multi-step reaction with 2 steps

2: platinum; acetic acid / 75 °C / 91938.4 Torr / Hydrogenation

With acetic acid; platinum;

DOI:10.1021/ja01097a016

upstream raw materials:

N-[2-(2-pyridyl)ethyl]-N'-methylpiperazine

1-methyl-piperazine

2-vinylpyridine