Remimazolam (benzenesulfonate)

Base Information

• Chemical Name: Remimazolam (benzenesulfonate)
• CAS No.: 1001415-66-2
• Molecular Formula: C27H25BrN4O5S
• Molecular Weight: 597.489
• Mol file: 1001415-66-2.mol

Synonyms:Remimazolam (benzenesulfonate)

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Chemical Property of Remimazolam (benzenesulfonate)

Chemical Property:

• PSA: 132.12000
• LogP: 5.63320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Remimazolam (benzenesulfonate)

There total 11 articles about Remimazolam (benzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

(3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3- yl]propionic acid methyl ester + benzenesulfonic acid (98-11-3) → 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (1001415-66-2)

Guidance literature:

In acetone; at 20 - 50 ℃; for 3h; Temperature; Inert atmosphere;

Reference yield: 79.0%

Remimazolam (308242-62-8) + benzenesulfonic acid (98-11-3) → 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (1001415-66-2)

Guidance literature:

In ethanol; Isopropyl acetate; for 0.25h; Product distribution / selectivity;

Reference yield: 62.43%

3-[(S)-7-bromo-2-(2-hydroxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester + benzenesulfonic acid (98-11-3) → 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (1001415-66-2)

Guidance literature:

3-[(S)-7-bromo-2-(2-hydroxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester; With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In dichloromethane; at 0 - 20 ℃; for 6h;

benzenesulfonic acid; In ethanol; ethyl acetate; for 6h; Reagent/catalyst;

upstream raw materials:

Remimazolam

benzenesulfonic acid

3-[(S)-7-bromo-2-(2-oxopropylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester

(3S)-3-(7-bromo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propionic acid methyl ester