1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid

Base Information

Chemical Name:1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid
CAS No.:1086423-47-3
Molecular Formula:C17H26N2O2Si
Molecular Weight:318.491
Hs Code.:
Mol file:1086423-47-3.mol

Synonyms:1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid;1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Suppliers and Price of 1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid

There total 1 articles about 1-(Triisopropylsilanyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1086423-47-3
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

2.2: 2 h

2.3: pH 2

3.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethanol / 43 h / 760.05 Torr

3.2: pH 4

With n-butyllithium; hydrogen; sec.-butyllithium; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane;

Reference yield:

: 1086423-47-3
1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

: 1086423-48-4
3-amino-4-methyl-N-(4-(morpholinomethyl)-3-(trifluoromethyl) phenyl)benzamide

: 1086422-78-7
1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid [2-methyl-5-(4-morpholin-4-ylmethyl-3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide

Guidance literature:: 1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0333333h;

3-amino-4-methyl-N-(4-(morpholinomethyl)-3-(trifluoromethyl) phenyl)benzamide; In N,N-dimethyl-formamide; at 20 ℃; for 168h;

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 50 ℃; for 0.5h;