1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid

Base Information

• Chemical Name: 1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid
• CAS No.: 1119451-22-7
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 1119451-22-7.mol

Synonyms:1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid

Chemical Property of 1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid

Chemical Property:

• PSA: 66.57000
• LogP: 3.19290

Purity/Quality:

98%min ^*data from raw suppliers

1-{[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]-methyl}piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid

There total 3 articles about 1-{[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methyl}piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isonipecotic acid (498-94-2) + [5-Methyl-2-(4-methylphenyl)-4-oxazolyl]methyl Chloride (137090-44-9) → 1-((5-methyl-2-(p-tolyl)oxazol-4-yl)methyl)piperidine-4-carboxylic acid (1119451-22-7)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00561

Reference yield:

4,5-dimethyl-2-(p-tolyl)oxazole 3-oxide → 1-((5-methyl-2-(p-tolyl)oxazol-4-yl)methyl)piperidine-4-carboxylic acid (1119451-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 1,2-dichloro-ethane / 0.5 h / Reflux

2: potassium hydroxide / ethanol / 16 h / 20 °C

With potassium hydroxide; trichlorophosphate; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.7b00561

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 1-((5-methyl-2-(p-tolyl)oxazol-4-yl)methyl)piperidine-4-carboxylic acid (1119451-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / acetic acid; 1,4-dioxane / 16 h / 0 - 20 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 0.5 h / Reflux

3: potassium hydroxide / ethanol / 16 h / 20 °C

With hydrogenchloride; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; acetic acid; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.7b00561

upstream raw materials:

isonipecotic acid

[5-Methyl-2-(4-methylphenyl)-4-oxazolyl]methyl Chloride

4-methyl-benzaldehyde

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