(1R)-3,3-difluorocyclopentane-1-carboxylic acid

Base Information

Chemical Name:(1R)-3,3-difluorocyclopentane-1-carboxylic acid
CAS No.:1352621-96-5
Molecular Formula:C6H8F2O2
Molecular Weight:150.125
Hs Code.:2916200090
Mol file:1352621-96-5.mol

Synonyms:(1R)-3,3-difluorocyclopentane-1-carboxylic acid;(R)-3,3-Difluorocyclopentanecarboxylic acid

Suppliers and Price of (1R)-3,3-difluorocyclopentane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-3,3-DifluorocyclopentanecarboxylicAcid
50mg
$ 90.00

Matrix Scientific
(R)-3,3-Difluorocyclopentanecarboxylicacid 95+%
1g
$ 2970.00

Crysdot
(R)-3,3-Difluorocyclopentanecarboxylicacid 95+%
250mg
$ 668.00

Crysdot
(R)-3,3-Difluorocyclopentanecarboxylicacid 95+%
100mg
$ 418.00

Crysdot
(R)-3,3-Difluorocyclopentanecarboxylicacid 95+%
1g
$ 1670.00

Chemenu
(R)-3,3-Difluorocyclopentanecarboxylicacid 95%
1g
$ 1561.00

Activate Scientific
(1R)-3,3-Difluorocyclopentane-1-carboxylic acid 95+% ee
100 mg
$ 389.00

Activate Scientific
(1R)-3,3-Difluorocyclopentane-1-carboxylic acid 95+% ee
1 g
$ 1501.00

Activate Scientific
(1R)-3,3-Difluorocyclopentane-1-carboxylic acid 95+% ee
250 mg
$ 670.00

ACHEMBLOCK
(1R)-3,3-Difluorocyclopentane-1-carboxylicacid 97%
1G
$ 1575.00

Total 6 raw suppliers

Chemical Property of (1R)-3,3-difluorocyclopentane-1-carboxylic acid

Chemical Property:

Boiling Point:222.6±40.0 °C(Predicted)
PKA:3.85±0.40(Predicted)
PSA：37.30000
Density:1.29±0.1 g/cm3(Predicted)
LogP:1.50640

Purity/Quality:

99%, ^*data from raw suppliers

(R)-3,3-DifluorocyclopentanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R)-3,3-difluorocyclopentane-1-carboxylic acid

There total 2 articles about (1R)-3,3-difluorocyclopentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1352621-94-3
(R)-benzyl 3,3-difluorocyclopentanecarboxylate

: 1352621-96-5
(R)-3,3-difluorocyclopentanecarboxylic acid

Guidance literature:: (R)-benzyl 3,3-difluorocyclopentanecarboxylate; With methanol; lithium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 1287745-32-7
(R)-benzyl 3-oxocyclopentanecarboxylate

: 1352621-96-5
(R)-3,3-difluorocyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / 1,1-dichloroethane / 10 - 40 °C

2.1: methanol; lithium hydroxide / 2 h / 20 °C

2.2: pH 3

With methanol; diethylamino-sulfur trifluoride; lithium hydroxide; In 1,1-dichloroethane;

Reference yield: 99.0%

: 1352621-96-5
(R)-3,3-difluorocyclopentanecarboxylic acid

: 1352621-92-1
(3S,4S)-4-(4-chlorophenyl)-3-methyl-1-D-valyl-3,4-piperidinediol

: 1352621-98-7
(R)-N-((R)-1-((3S,4S)-4-(4-chlorophenyl)-3,4-dihydroxy-3-methylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3,3-difluorocyclopentanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;