benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride

Base Information

Chemical Name:benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride
CAS No.:220009-35-8
Molecular Formula:C₁₆H₂₆N₂O₅
Molecular Weight:326.393
Hs Code.:
Mol file:220009-35-8.mol

Synonyms:1,7-Diazaspiro[4.5]decane-7-acetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-6-oxo-, Methyl ester

Suppliers and Price of benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride

Chemical Property:

PSA：76.15000
LogP:1.42730

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride

There total 8 articles about benzyl 7-(2-methoxy-2-oxo-ethyl)-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 220009-35-8
7-Methoxycarbonylmethyl-6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Cs₂CO₃ / 1.) MeOH, 2.) DMF

2: 65 percent / LDA

3: 1.) BH₃*THF, 2.) H₂O₂, KOH

4: 1.) oxalyl chloride, DMSO, 2.) Et₃N

5: DIPEA / methanol

6: NaBH₄ / methanol

7: H₂ / Pd(OH)2/C

8: EDCI, NMM

With 4-methyl-morpholine; potassium hydroxide; sodium tetrahydroborate; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; caesium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; In methanol;
DOI:10.1016/S0960-894X(98)00577-0

Reference yield:

: 37787-77-2
Boc-L-proline benzyl ester

: 220009-35-8
7-Methoxycarbonylmethyl-6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / LDA

2: 1.) BH₃*THF, 2.) H₂O₂, KOH

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N

4: DIPEA / methanol

5: NaBH₄ / methanol

6: H₂ / Pd(OH)2/C

7: EDCI, NMM

With 4-methyl-morpholine; potassium hydroxide; sodium tetrahydroborate; borane-THF; oxalyl dichloride; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium dihydroxide; In methanol;
DOI:10.1016/S0960-894X(98)00577-0

Reference yield:

: 220009-70-1
2-(3-Hydroxy-propyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

: 220009-35-8
7-Methoxycarbonylmethyl-6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N

2: DIPEA / methanol

3: NaBH₄ / methanol

4: H₂ / Pd(OH)2/C

5: EDCI, NMM

With 4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol;
DOI:10.1016/S0960-894X(98)00577-0